Hahn, K.M., Itano, M.S., Loew, L.M., and Vitriol, E.A. Celebrating the creative scientific life of Ken Jacobson. Biophys J. Special edition honoring Ken Jacobson, 122(18): E1-E4, 2023. Online article | PMC Free article (available on 2024-09-19)
Herron, J.C., Hu, S., Watanabe, T., Nogueira, A.T., Liu, B., Kern, M.E., Aaron, J., Taylor, A., Pablo, M., Chew, T-L., Elston, T.C., and Hahn, K.M. Actin nano-architecture of phagocytic podosomes. Nature Communications, 13: 4363, 2022. PMC9329332. Free online article | Free PMC article
Liu, B., Stone, O.J., Pablo, M., Herron, C.J., Nogueira, A.T., Dagliyan, O., Grimm, J.B., Lavis, L.D., Elston, T.C., and Hahn, K.M. Biosensors based on peptide exposure show single molecule conformations in live cells. Cell, 184(22): 5670-5685, 2021. PMC8556369. Online article | Free PMC article available 10/28/22
Marston, D.J., Vilele, M., Huh, J., Ren, J., Azoitei, M., Glekas, G., *Danuser, G., *Sondek, J., and *Hahn, K.M. Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis.. Nature Chem. Biol., 16(8): 826-833, 2020. PMC7388658. Online article | Free PMC article
Stone, O.J., Pankow, N., Liu, B., Sharma, V.P., Eddy, R.J., Wang, H., Putz, A.T., Teets, F.D., Kuhlman, B., *Condeelis, J.S., and *Hahn, K.M. Optogenetic control of Cofilin and aTAT in living cells using Z-lock. Nature Chemical Biology, 15: 1183-1190, 2019. PMC6873228. Online article | Free PMC article
Azoitei, M.L., Noh, J., Marston, D.J., Roudot, P., Marshall, C.B., Daugird, T.A., Lisanza, S.L., Sandí, M.J., Ikura, M., Sondek, J., Rottapel, R., *Hahn, K.M., and *Danuser, G. Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways. J. Cell Biol., 218(9): 3077-3097, 2019. PMC6719461. Online article | Free PMC article
Dagliyan, O., Tarnawski, M., Chu, P-H., Shirvanyants, D., Schlichting, I., Dokholyan, N.V., and Hahn, K.M. Engineering extrinsic disorder to control protein activity in living cells. Science, 354(6318): 1441-1444, 2016. PMC5362825. View free in Science online: Full text | Abstract | Reprint | Free PMC article
Wang, W., Vilela, M., Winkler, A., Tarnawski, T., Schlichting, I., Yumerefendi, H., Kuhlman, B., Liu, R., Danuser, G., and Hahn, K.M. LOVTRAP, An Optogenetic System for Photo-induced Protein Dissociation. Nature Methods, 13(9): 755-8, 2016. PMC5137947. Online article | Free PMC article
Hodgson, L., Spiering, D., Sabouri-Ghomi, M., DerMardirossian, C., Danuser, G., and Hahn, K.M. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nature Chem. Biol., 12(10): 802-9, 2016. PMC5030135. Online article | Free PMC article
Hayashi-Takagi, A., Yagishita, S., Nakamura, M., Shirai, F., Wu, Y.I., Loshbaugh, A.L., Kuhlman, B., Hahn, K.M., and Kasai, H. Labelling and optical erasure of synaptic memory traces in the motor cortex. Nature, 525(7569): 333-8, 2015. PMC4634641. Online article | Free PMC article
Yi, J.J., Berrios, J., Newbern, J.M., Snider, W.D., Philpot, B.D., Hahn, K.M., and Zylka, M.J. An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A. Cell, 162(4):795-807, 2015. PMC4537845. Online article | Free PMC article
Chu, P-H., Tsygankov, D., Berginski, M.E., Dagliyan, O., Gomez, S.M., Elston, T.C., Karginov, A.V. and Hahn, K.M. Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc. Natl. Acad. Sci. U.S.A.,111(34): 12420–12425, 2014. PMC4151743. Online article | Free PMC article
Karginov, A., Tsygankov, D., Berginski, M., Chu, P-H., Trudeau, E., Yi, J.J., Gomez, Shawn, Elston, T.C. and Hahn, K.M. Dissecting motility signaling through activation of specific Src-effector complexes. Nature Chem. Biol., 10(4):286-90, 2014. PMC4064790. Online article | Free PMC article
Dagliyan, O., Shirvanyants, D., Karginov, A.V., Ding, F., Fee, L., Chandrasekaran, S.N., Freisinger, C.M., Smolen, G.A., Huttenlocher, A., Hahn, K.M., Dokholyan, N.V. Rational design of a ligand-controlled protein conformational switch. Proc. Natl. Acad. Sci. U.S.A., 110(17):6800-4, 2013. PMC3637791. Online article | Free PMC article
Wang, X., He L, Wu, Y.I., Hahn, K.M., and Montell, D.J. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nature Cell Biol., 12(6):591-7, 2011. PMC2929827. Online article | Free PMC article
Karginov, A.V., Ding, F., Kota, P., Dokholyan, N.V., and Hahn, K.M. Engineered allosteric activation of kinases in living cells. Nature Biotech, July; 28(7): 743-7, 2010. PMC2902629. Online article | Free PMC article
Koivusalo, M., Welch, C., Hayashi, H., Scott, C.C., Kim, M., Alexander, T., Touret, N., Hahn, K.M., and Grinstein, S. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signalling. J. Cell Biol., 188: 547-563, 2010. PMC2828922. Online article | Free PMC article
Yoo, S.K., Deng, Q., Cavnar, P. J., Wu,Y.I., Hahn, K.M., Huttenlocher, A. Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish. Developmental Cell, 18(2):226-236, 2010. PMC2824622. Online article | Free PMC article
Wu, Y, Frey, D., Lungu, O. I., Jaehrig, A., Schlichting, I., Kuhlman, B. and Hahn, K.M. A genetically encoded photoactivatable Rac controls the motility of living cells. Nature, 461:104-108, 2009. PMC2766670. Online article | Free PMC article
Machacek, M., Hodson, L., Welch, C., Elliot, H., Pertz, O., Nalbant, P., Abell, A., Johnson, G., *Hahn, K.M. and *Danuser, G. Coordination of Rho GTPase activities during cell protrusion. Nature, 461:99-103, 2009. PMC2885353. Online article | Free PMC article
Toutchkine, A., Dan-Vinh Nguyen, D., and Hahn, K.M. Merocyanine dyes with improved photostability. Org. Lett., 9: 2775-2777, 2007. Online article.
Birkenfeld, J., Nalbant, P., Bohl, B.P., Pertz, O.P., Hahn, K.M., and Bokoch, G.M. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Developmental Cell. 12:699-712, 2007. PMC1965589. Online article | Free PMC article
Wong, K., Pertz, O., Hahn, K. and Bourne, H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc. Natl. Acad. Sci. U.S.A., 103: 3639-3644, 2006. PMC1450135. Online article | Free PMC article
Pertz, O., Hodgson, L., Klemke, R.R., and Hahn, K.M. Spatio-temporal dynamics of RhoA activity in migrating cells. Nature, 440(7087):1069-1072, 2006. Online article | PDF
Subauste, M., Pertz, O., Adamson, E., Turner, C.E., Junger, S. and Hahn, K.M. Vinculin modulation of Paxillin-FAK interactions regulates ERK to control survival and motility. J. Cell Biol., 165: 171-181, 2004. PMC2172187. Online article | Free PMC article
Nalbant, P., L. Hodgson, V. Kraynov, A. Toutchkine, K.M. Hahn. Activation of Endogenous Cdc42 Visualized in Living Cells. Science, 305:1615-1619, 2004. Online article.
Toutchkine, A., V. Kraynov, and K.M. Hahn. Solvent-Sensitive Dyes to Report Protein Conformational Changes in Living Cells. J. Amer. Chem. Soc., 125:4132-4145, 2003. Online article.
Katsumi, A., Milanini, J., Kiosses, W.B., del Pozo, M.A., Kaunas, R., Chien, S., Hahn, K.M. and Schwartz, M.A. Effects of cell tension on membrane protrusion through regulation of the GTPase Rac. J. Cell Biol., 158: 1-13, 2002. PMC2173027. Online article | Free PMC article
Del Pozo, M.A., W.B. Kiosses, N.B. Alderson, N. Meller, K.M. Hahn, and A. Schwartz. Integrin-regulated membrane translocation of GTP-Rac induces localized interaction with effectors due to dissociation of RhoGDI. Nature Cell Biol., 4:232-239, 2002. Online article.
Kraynov, V. S., Chamberlain, C. E., Bokoch, G. M., Schwartz, M. A., Slabaugh, S., and K. M. Hahn. Localized Rac activation dynamics visualized in living cells. Science, 290:333-337, 2000. Online article.
Bark, S. J., S. Schmid, and K.M. Hahn. A highly efficient method for site specific modification of peptides after chemical synthesis. J. Am. Chem. Soc., 122 (15): 3567-3573, 2000. [above link downloads PDF] | Online article
Subauste, C.M., Von Herrath, M., Benard, V., Chamberlain, C.E., Chuang, T.H., Chu, K., Bokoch, G.M. and Hahn, K.M. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and fas. J. Biol. Chem., 275 (3): 9725-9733, 2000. Online article | PDF
Cornish, V. W., K. M. Hahn, and P. G. Schultz. Site-specific protein modification using a ketone handle. J. Am. Chem. Soc., 118: 8150-8151, 1996. Online article | PDF
Hahn, K.M., R. DeBiasio and D.L. Taylor. Patterns of elevated free calcium and calmodulin activation in living cells. Nature, 359:736-738, 1992. Online article | PDF
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