Upon photo-inhibition, Src translates to focal adhesions and induces polarized movement.

by Onur Dagliyan
Science, 354(6318):1441-1444, 2016
Copyright Hahn Lab UNC Chapel Hill

SYF cell expressing photo-inhibitable Src (PI-Src). Irradiation caused the PI-Src to reversibly translocate to focal adhesions. This was accompanied to varying degrees by cell polarization, cell translation, and increased edge dynamics. Blue dot indicates irradiation. Cell was visualized using PI-Src-mCherry. By Onur Dagliyan.