Multiplexed optogenetic control, using photo-activatable Vav2 (PA-Vav2) and photo-inhibitable Rac1 (PI-Rac1) in the same cell
by Onur Dagliyan
Science, 354(6318):1441-1444, 2016
Upon irradiation, area and roundness changed as they did in response to PA-Vav2 alone, but edge dynamics were clearly reduced, unlike response to either PA-Vav2 alone or PI-Rac1 alone. Blue dot denotes irradiation. Cells were visualized using mVenus-PI-Rac1. By Onur Dagliyan.