Megakaryocyte proplatelet extensions

by Ellen O'Shaughnessy and Ana Nogueria
Lab Chip, 22(1): 136–147, 2021.
Copyright Hahn Lab UNC Chapel Hill

Megakaryocytes in late pro-platelet formation have dynamic cellular protrusions. Volume rendering of MKs in late pro-platelet formation demonstrates highly dynamic, thin cellular protrusions prior to budding into pro-platelets. MKs labeled with anti-GPIX-647 and imaged with lattice light sheet microscopy. The cubic scale bar covers a 10 μm x 10 μm x 10 μm volume.