hahn lab

RapR TAP


Unlike with normal kinases that interact with multiple substrates, with RapR-TAP a specific kinase is activated to interact with only one specific target (right). Activation occurs when addition of rapamycin leads to interaction of two engineered domains (yellow), on the kinase and on the target.

Karginov, A., Tsygankov, D., Berginski, M., Chu, P-H., Trudeau, E., Yi, J.J., Gomez, Shawn, Elston, T.C. and Hahn, K.M. Dissecting motility signaling through activation of specific Src-effector complexes. Nature Chem. Bio., 10(4):286-90, 2014.  PMC4064790. Online article | Free PMC article

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