hahn lab

Shiqiong Hu

Dan Marston

I was broadly trained in cell biology and mechanobiology at Ecole Normale Supérieure de Lyon and the Mechanobiology Institute of Singapore. I am particularly interested in ultrastructure and self-organization of the actomyosin cytoskeleton and adhesions in non-muscle and immune cells. In the Hahn lab, I am focused on macrophage function and and cytoskeletal dynamics using a “frustrated phagocytosis” model, in which cells respond to substrates with precisely controlled geometries. Using several types of super-resolution imaging techniques, we have shown that actin and adhesion proteins play critical roles in organizing phagocytic structures composed of actin, adhesion molecules and motor proteins. We have defined the kinetics and distribution of podosome structural changes in this model, and are now developing the ability to control receptor and membrane dynamics with light.

 

 

 

~Updated 04/07/2021

© UNC Department of Pharmacology