hahn lab

image analysis and quantitative imaging; microscope automation

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Marston, D.J., Anderson, K.L., Swift, M.F., Rougie, M., Page, C., Hahn, K.M., Volkmann, N., and Hanein, D. High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture.Proc. Natl. Acad. Sci. U.S.A., 116(4):1267-1272, 2019. PMC6347697. Online article | Free PMC Article [Available July 22, 2019]

Zhurikhina, A., Qi, T., Hahn, K.M., Elston, T.C., and Tsygankov, D. EdgeProps: A. Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity. Methods Mol Biol., 1821:47-56, 2018. doi: 10.1007/978-1-4939-8612-5_4. Online article

Ma, X., Dagliyan, O., Hahn, K.M., and Danuser, G. Profiling cellular morphodynamics by spatiotemporal spectrum decomposition. PLoS Comput. Biol., 14(8):e1006321, 2018. doi: 10.1371/journal.pcbi.1006321. PMC6091976. Online open access article | Free PMC article

Taylor, A.B., Joannou, M.S., Watanabe, T., Hahn, K., Chew, T.L. Perceptually accurate display of two greyscale images as a single colour image. J. Microsc., 268(1): 73-83, 2017. PMC5637524. Online article | Free PMC article

Tsygankov, D., Chu, P-H., Chen, H., Elston, T.C. and Hahn, K.M. User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters. Methods Cell Biol., 123: 409-427, 2014. PMC4504218. Online article | Free PMC article

Slattery, S.D. and Hahn, K.M. A high content assay for biosensor validation and for examining stimuli that affect biosensor activity.  Current Protocols in Cell Biology, 2014, 65:14.15.1–14.15.31. PMC4324324. Online article | Free PMC article

Hinde, E., Yokomori, K., Gaus, K., Hahn, K.M. and Gratton, E. Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Scientific Reports, 4: 4219, 2014.  PMC393623. Online article | Free PMC article

Tsygankov, D., Bilancia, C.G., Vitriol, E.A., Hahn, K.M., Peifer, M. and Elston, T.C. CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries. J. Cell Biol., 204(3): 443-460, 2014. PMC3912527. Online article | Free PMC article

Allen, R. J., Tsygankov, D., Zawistowski, J. S., Elston, T. C. and Hahn, K.M. Automated line scan analysis to quantify biosensor activity at the cell edge. Methods, 66(2014): 162–167, 2014. PMC4296898. Online article | Free PMC article

Hinde, E., Digman, M.A., Hahn, K.M. and Gratton, E. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc. Natl. Acad. Sci. U.S.A., 110(1): 135-140, 2013. PMC3538204. Online article| Free PMC article

Vilela, M., Halidi, N., Besson, S., Elliott, H., Hahn, K., Tytell, J. and Danuser, G. Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways. Methods Enzymol., 519: 253-276, 2013.  PMC4174660. Online article | Free PMC article

Hinde, E., Digman, M.A., Welch, C., Hahn, K.M. and Gratton, E. Biosensor FRET detection by the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). Microsc. Res. Tech., 75(3): 271-281, 2012.  PMC3523109 . Online article | Free PMC article

Berginski, M.E., Vitriol, E.A., *Hahn, K.M. and *Gomez, S.M. High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS ONE, 6: e22025, 2011. PMC3136503. Online article | Free PMC article

Shen, F., Hodgson, L., Price, J.H. and Hahn, K.M. Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Cytometry A., 73: 658-666, 2008. [link downloads PDF]

Malone, M.H., Sciaky, N., Stalheim, L., Hahn, K.M., Linney, E. and Johnson, G.L. Laser-scanning velocimetry: A confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol., 7: 40, 2007. PMC1955438. Online article PDF | [link goes to Free PMC article]

Shen, F., Hodgson, L. and Hahn, K.M. Digital autofocus methods for automated microscopy. Methods Enzymol., 414: 620-632, 2006. Online article | Download PDF

Bark, I.C., Hahn, K.M., Ryabinin, A.E. and Wilson, M.C. Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neuronal development. Proc. Natl. Acad. Sci. U.S.A., 92: 1510-1514, 1995. PMC42549. Onilne article | Free PMC article

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