hahn lab

image analysis, quantitative imaging, and microscopy

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Slattery, S.D. and Hahn, K.M. A high content assay for biosensor validation and for examining stimuli that affect biosensor activity.  Current Protocols in Cell Biology, 2014, 65: 14.15.1–14.15.31. PMC4324324

Chu, P-H., Tsygankov, D., Berginski, M.E., Dagliyan, O., Gomez, S.M., Elston, T.C., Karginov, A.V., and Hahn, K.M. Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc. Natl. Acad. Sci. U.S.A. 111(34):12420–12425, 2014. PMC4151743

Tsygankov, D., Chu, P-H., Chen, H., Elston, T.C. and Hahn, K.M.  User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters. Methods in Cell Biol., 123:409-427, 2014. PMC4504218

Hinde, E., Yokomori, K, Gaus, K., Hahn, K.M., Gratton, E. Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Scientific Reports 4:4219, 2014.  PMC3936235

Tsygankov, D., Bilancia, C.G., Vitriol, E.A., Hahn, K.M., Peifer, M. and Elston, T.C. CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries. J. Cell Biol. 204(3): 443-460, 2014. PMC3912527

Allen, R. J., Tsygankov, D., Zawistowski, J. S., Elston, T. C.,  and Hahn, K. M. Automated line scan analysis to quantify biosensor activity at the cell edge. Methods 66(2014): 162–167, 2014. PMC4296898

Hinde, E., Digman, M.A., Hahn, K.M., and Gratton, E. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U.S.A. 110(1): 135-40, 2013. PMC3538204

Vilela M, Halidi N, Besson S, Elliott H, Hahn K, Tytell J, Danuser G. Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways. Methods Enzymol.  519:253-76, 2013.  PMC4174660

Hinde, E., Digman, M.A., Welch, C., Hahn, K.M., and Gratton, E. Biosensor FRET detection by the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). Microsc Res Tech 75(3): 271-81, 2012.  PMC3523109

Shadpour, H., Zawistowski, J.S., Herman, A., Hahn, K.M., and Allbritton, N.L.  Patterning pallet arrays for cell selection based on high-resolution measurements of fluorescent biosensors. Analytica Chimica Acta, 696: 101-107, 2011. PMC3104244

Berginski, M.E., Vitriol, E.A., Hahn, K.M.*, and Gomez, S.M.*  High-Resolution Quantification of Focal Adhesion Spatiotemporal Dynamics in Living Cells. PLoS ONE, 6: e22025, 2011. PMC3136503

Jacobson, K., Raijfur, Z., Vitriol, E., and Hahn, K.M. Chromophore-assisted laser inactivation in cell biology. Trends in Cell Biology.  18(9):443-450, 2008. PMC4445427

Sabouri-Ghomi, M., Wu, Y., Hahn, K., and Danuser, G. Visualizing and quantifying adhesive signals. Curr Opin. Cell Biol. 20:541-550, 2008.  PMC2661108

Shen, F., Hodgson, L., Price, J.H., and Hahn, K.M. Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Cytometry A. 73:658-66, 2008.

Malone, M.H., Sciaky, N., Stalheim, L., Hahn, K.M., Linney, E., Johnson, G.L. Laser-scanning velocimetry: A confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnology, 7:40, 2007. PMC1955438

Wang, Y.L., Hahn, K.M, Murphy, R.F., and A.F. Horwitz. From imaging to understanding: Frontiers in live cell imaging. J Cell Biol. 174(4): 481-484, 2006. PMC2064253

Shen, F., Hodgson, L. and Hahn, K.M. Digital autofocus methods for automated microscopy. Methods Enzymol., 414:620-632, 2006.

Hodgson, L. Nalbant, P. Shen, F., and Hahn, K. Imaging and photobleach correction of Mero-CBD, sensor of endogenous Cdc42 activation. Methods Enzymol., 406:140-156, 2006.

Shen, F., L. Hodgson, A. Rabinovich, O. Pertz, K. M. Hahn, and J. H. Price. Functional Proteomics for Cell Migration. Cytometry, 69:563-782, 2006.

Price, J., A. Goodacre, K.M. Hahn, L. Hodgson, E. Hunter, S. Krajewski, R.F. Murphy, A. Rabinovich, J.C. Reed, and S. Heynen. Advances in Molecular Labeling, High Throughput Imaging and Machine Intelligence Portend Powerful Functional Cellular Biochemistry Tools. J. Cell. Biochem39:194-210, 2003.

Subauste, C., B. List, X. Guan, K.M. Hahn, R. Lerner and N.B. Gilula. A catalytic antibody produces fluorescent tracers of gap junction communication in living cells. J. Biol. Chem. 276:49164-49168, 2001.

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