hahn lab

engineered allosteric networks in proteins

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Dagliyan, O., Tarnawski, M., Chu, P-H., Shirvanyants, D., Schlichting, I., Dokholyan, N.V., and Hahn, K.M. Engineering extrinsic disorder to control protein activity in living cells.  Science, 354(6318): 1441-1444, 2016.

Karginov, A., Tsygankov, D., Berginski, M., Chu, P-H., Trudeau, E., Yi, J.J., Gomez, Shawn, Elston, T.C. and Hahn, K.M. Dissecting motility signaling through activation of specific Src-effector complexes. Nat. Chem. Bio. 10(4):286-90, 2014.  PMC4064790

Dagliyan, O., Shirvanyants, D., Karginov, A.V., Ding, F., Fee, L., Chandrasekaran, S.N., Freisinger, C.M., Smolen, G.A., Huttenlocher, A., Hahn, K.M.*, Dokholyan, N.V.* Rational design of a ligand-controlled protein conformational switch. Proc. Natl. Acad. Sci. U. S. A. 110(17): 6800-4, 2013. PMC3637791

Karginov, A.V., and Hahn, K.M. Allosteric activation of kinases: design and application of RapR kinases. Curr. Protoc. Cell Biol., Chapter 14:Unit 14.13, 2011. PMC3269071

Karginov, A.V., Zou, Y.,  Shirvanyants, D., Kota, P., Dokholyan, N.V., Young, D.D., Hahn, K.M.*, and Deiters, A.*  Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP. J. Am. Chem. Soc., 133: 420-423, 2011. PMC3133816

Karginov, A., Ding, F., Kota, P., Dokholyan, N.V., and Hahn, K.M. Engineered allosteric activation of kinases in living cells. Nature Biotech.,28(7): 743-7, 2010.  PMC2902629          

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