hahn lab

cell biology & physiology

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Takano, T., Wu, M., Nakamuta, S., Naoki, H., Ishizawa, N., Namba, T., Watanabe, T., Xu, C., Hamaguchi, T., Yura, Y., Amano, M., Hahn, K.M. and Kaibuchi, K. Discovery of long-range inhibitory signaling to ensure 0.3 single axon formation. Nature Communications, Jun 26; 8(1):33, 2017. PMC5484694

Nguyen, T.T., Park, W.S., Park, B.O., Kim, C.Y., Oh, Y., Kim, J.M., Choi, H., Kyung, T., Kim, C.H., Lee, G., Hahn, K.M., Meyer, T., and Heo, W.D. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A., 113(36): 10091-6, 2016. PMC5018766.

Hodgson, L., Spiering, D., Sabouri-Ghomi, M., DerMardirossian, C., Danuser, G., and Hahn, K.M. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nature Chem. Biol., 12(10): 802-9, 2016. PMC5030135.

Wang, W., Vilela, M., Winkler, A., Tarnawski, T.,  Schlichting, I., Yumerefendi, H., Kuhlman, B., Liu, R., Danuser, G., and Hahn, K.M. LOVTRAP, An Optogenetic System for Photo-induced Protein Dissociation. Nature Methods, 13(9): 755-8, 2016.

Yumerefendi, H., Lerner, A.M., Zimmerman, S.P., Hahn, K.M., Bear, J.E., Strahl, B.D., and Kuhlman, B. Light-induced nuclear export reveals rapid dynamics of epigenetic modifications. Nature Chem. Biol., 12(6):399-401, 2016. PMC4888063

Hayashi-Takagi, A., Yagishita, S., Nakamura, M., Shirai, F., Wu, Y.I., Loshbaugh, A.L., Kuhlman, B., Hahn, K.M., and Kasai, H. Labelling and optical erasure of synaptic memory traces in the motor cortex. Nature, 525(7569): 333-8, 2015. PMC4634641.

Yi, J.J., Berrios, J., Newbern, J.M., Snider, W.D., Philpot, B.D., Hahn, K.M., and Zylka, M.J. An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A. Cell, 162(4):795-807, 2015. PMC4537845

Yumerefendi, H., Dickinson, D.J., Wang, H., Zimmerman, S., Bear, J.E.,  Goldstein, B., Hahn. K.M. and Kuhlman, B. Control of protein activity and cell fate specification via light-mediated nuclear translocation. PLoS One, 10(6): e0128443,2015. PMC4471001

Karginov, A., Tsygankov, D., Berginski, M., Chu, P-H., Trudeau, E., Yi, J.J., Gomez, Shawn, Elston, T.C. and Hahn, K.M. Dissecting motility signaling through activation of specific Src-effector complexes. Nat. Chem. Bio. 10(4):286-90, 2014.  PMC4064790

Khalil, B.D., Hanna, S., Saykali, B.A., El-Sitt, S., Nasrallah, A., Marston, D., El-Sabban, M., Hahn, K.M., Symons, M., and El-Sibai, M. The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Exp. Cell Res. 321(2):109-122, 2014. PMC4297755

Zawistowski, J.S., Sabouri-Ghomi, M., Danuser, G., Hahn, K.M.*, and Hodgson, L. A.* RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells. PLoS One 8(11): e79877, 2013. PMC3818223

Collins, C., Guilluy, C., Welch, C., O’Brien, E.T., Hahn, K.M., Superfine, R., Burridge,K., and Tzima, E.  Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr. Biol. 22(22): 2087-94, 2012. PMC3681294

Galic, M., Jeong, S., Tsai, F-C., Joubert, L-M.,  Wu, Y.I., Hahn, K.M., Cui, Y., and Meyer, T. External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nature Cell Biol., 14(8): 874-81, 2012.  PMC3519285

Dietz, D.M., Sun H., Lobo M.K., Cahill M.E., Chadwick B., Gao V., Koo J.W., Mazei-Robison M.S., Dias C., Maze I., Damez-Werno D., Dietz K.C., Scobie K.N., Ferguson D., Christoffel D., Ohnishi Y., Hodes G.E., Zheng Y., Neve R.L., Hahn K.M., Russo S.J., Nestler E.J. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature Neuroscience, 15(6): 891-896, 2012.  PMC3565539

Helfand, B.T., Mendez,, M.G., Murthy, S.N.P., Shumaker, D.K., Grin, B., Mahammad, S., Ueli Aebi, U.,  Wedig, T., Wu, Y.I., Hahn, K.M., Inagaki, M., Herrmann, H., and Goldman, R.D.  Vimentin organization modulates the formation of lamellipodia. Mol. Biol. Cell, 22: 1274-1289, 2011. PMC3078081

Samson, T., Welch, C.M., Monaghan-Benson, E., Hahn, K.M., and Burridge, K. Endogenous RhoG is Rapidly Activated after EGF Stimulation through Multiple GEFs. Mol. Biol. Cell, 21(9): 1629-42, 2010. PMC2861620

Wang, X. He, L., Wu, Y., Hahn, K. M., and Montell, D. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat. Cell Biol., 12(6): 591-7, 2010.  PMC2929827        

Koivusalo, M., Welch, C., Hayashi, H., Scott, C.C., Kim, M., Alexander, T., Touret, N., Hahn, K.M., and Grinstein, S. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signalling. J. Cell Biol., 188: 547-563, 2010. PMC2828922

Yoo, S.K., Deng, Q.,  Cavnar, P. J.,  Wu,Y.I.,  Hahn, K.M., Huttenlocher, A. Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish.  Developmental Cell, 18: 226-236, 2010. PMC2824622

Wu, Y, Frey, D., Lungu, O. I., Jaehrig, A., Schlichting, I., Kuhlman, B. and Hahn, K.M. Genetically-encoded photoactivatable Rac reveals spatiotemporal coordination of Rac and Rho during cell motility. Nature, 461: 104-110, 2009. PMC2766670

Machacek, M., Hodson, L., Welch, C., Elliot, H., Pertz, O., Nalbant, P., Abell, A., Johnson, G., Hahn, K.M.* and Danuser, G.* Coordination of Rho GTPase activities during cell protrusion. Nature, 461: 99-103, 2009. PMC2885353

Su, L., Pertz, O., Mikawa, M., Hahn, K.M., and Parsons, S.J. p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells. Exper.Cell Res., 315: 1347-59, 2009. PMC2731427

Manukyan, M., Nalbant, P., Hahn, K.M., and Knaus, U.G. RhoA GTPase activation by TLR ligands: connecting via Src to NF-kB. J. Immunol. 182(6):3522-3529, 2009. PMC2684960

El-Sibai, M., Pertz, O., Pang, H., Yip, S.C., Lorenz, M., Symons, M., Condeelis, J.S., Hahn, K.M, and Backer, J.M. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp. Cell Res. 314:1540-52, 2008. PMC2677995

Healy, K.D., Hodgson, L., Kim, T.Y., Shutes, A., Maddileti, S., Juliano, R.L., Hahn, K.M., Harden, T.K., Bang, Y.J., Der, C.J. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog. 47(5):326-37, 2008. PMC2679972

 Frantz, C.,  Karydis, A., Nalbant, P., Hahn, K. M., and Barber, D. L.  Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells.  J. Cell Biol. 179: 403-410, 2007. PMC2064788

El-Sibai, M., Nalbant, P., Sarmiento, C., Macaluso, F., Cammer, M, Condeelis, J.S., Hahn, K.M. and Backer, J.M. Cdc42 is Required for EGF-Stimulated Protrusion and Motility in Carcinoma Cells. J. Cell Science, 120(Pt 19):3465-74, 2007.

Birkenfeld, J., Nalbant, P., Bohl, B.P., Pertz, O.P., Hahn, K.M., and Bokoch, G.M. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Developmental Cell. 12:699-712, 2007. PMC1965589

Van Keymeulen, A., Wong, K., Knight, Z.A., Govaerts, C., Hahn, K.M., Shokat, K.M., and Bourne, H.R. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J. Cell Biol., 174:437-445, 2006. PMC2064239

Nakamura, K., Uhilk, M.T., Johnson, N.L., Hahn, K.M., and Johnson, G.L. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol. Cell Biol., 26:2065-2079, 2006. PMC1430298

Wong, K., Pertz, O., Hahn, K., and Bourne, H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A., 103:3639-44, 2006. PMC1450135

Pertz, O., Hodgson, L., Klemke, R., and Hahn, K.M.  Spatio-temporal dynamics of RhoA activity in migrating cells. Nature, 440:1069-1072, 2006.

Subauste, M., P. Nalbant E. Adamson,  K. M. Hahn. Vinculin Controls PTEN Protein Level by Maintaining the Interaction of the Adherens Junction Protein a-Catenin with the Scaffolding Protein MAGI-2. J. Biol. Chem, 165:371-381, 2005.

Subauste, M., O. Pertz, E. Adamson, C. E. Turner, S. Junger, K. M. Hahn. Vinculin modulation of Paxillin-FAK interactions regulates ERK to control survival and motility. J. Cell Biol., 165:171-181, 2004. PMC2172187

Tu, S.S., Wen, J.W., Yang, W., Nalbant, P., Hahn, K.M., and Cerione, R.A. Anti-apoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry, 41:12350-12358, 2002.

Gardiner, E.M., N. Pestonjamasp, B.P. Bohl, C. Chamberlain, K.M. Hahn, and G.M. Bokoch. Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis:  Roles in leading edge extension and tail retraction. Current Biology, 12:2029-2034, 2002.

Katsumi, A., J. Milanini, W.B. Kiosses, M.A.del Pozo, R. Kaunas, S. Chien, K.M. Hahn, and M.A. Schwartz. Effects of cell tension on membrane protrusion through regulation of the GTPase Rac. J. Cell Biol., 158:1-13, 2002. PMC2173027

Nishimura, N., H. Pluttner, K.M. Hahn, and W.E. Balch. The δ subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface. Proc. Natl. Acad. Sci., USA, 99:6755-6760, 2002.

Del Pozo, M.A., W.B. Kiosses, N.D. Alderson, N. Meller, K.M. Hahn and M. A. Schwartz. Integrin regulated membrane translocation of GTP-Rac induces localized interaction with effectors due to dissociation of RhoGDI. Nature Cell Biol., 4:232-239, 2002.

Frosst, P., T. Guan, C. Subauste, K.M. Hahn and L. Gerace. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J.Cell Biol., 156: 617-630, 2002. PMC2174070

Weiss, T. S., C. E. Chamberlain, T. Takeda, P. Lin, K. M Hahn and M. G. Farquhar. Live-Cell fluorescence resonance energy transfer (FRET) shows Interaction between Gai3 on golgi membranes and the cytosolic pool of calnuc. Proc. Natl. Acad. Sci., USA. 98:14961-14966, 2001. PMC64966

Kiosses, W. B., K. M. Hahn, G. Giannelli, and V. Quaranta.  Characterization of morphological and cytoskeletal changes in MCF10A breast epithelial cells plated on laminin-5: comparison with breast cancer cell line MCF7.  Cell Adhes. Commun., 8:29-44,  2001.

Kraynov, V. S., C. E. Chamberlain, G. M. Bokoch, M. A. Schwartz, S. Slabaugh and K.M. Hahn. Localized Rac Activation Dynamics Visualized in Living Cells. Science, 290:333-337, 2000.

Subauste, C. M., M. Von Herrath, V. Benard, C. E. Chamberlain, T. H. Chuang, K. Chu, G. M. Bokoch, and K.M. Hahn. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and fas. J. Biol. Chem., 275 (3): 9725-9733, 2000.

Stupack, D.G., E. Li, J.A. Kehler, R.A. Geahlen, K.M. Hahn, G.R. Nemerow, and D.A. Cheresh. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J. Cell Biol., 144:777-787, 1999. PMC2132930

Nishimura, N., S. Bannykh, S. Slabaugh, J. Matteson K.M. Hahn, and W.E. Balch. The Di-Acidic (DxE) Code Found in the Cytoplasmic Domain of Cargo Directs Concentration During Export from the Endoplasmic Reticulum. J. Biol. Chem., 274: 15937-15946, 1999.

Ben-Ami, G., V. Ozeri, E. Hanski, F. Hofmann, K. Aktories, K.M. Hahn, G.M. Bokoch,and I. Rosenshine.  Agents that inhibit Rho, Rac and Cdc42 do not block formation of actin pedestals in HeLa cells infrected with enteropathogenic Escherichia coli. Infect. Immun., 66: 1755-1758, 1998. PMC108116

Chuang, T.H., K.M. Hahn, J.D. Lee, D.E. Danley, and G.M. Bokoch.  The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.  Mol.Biol. Cell, 8: 1687-1698, 1997. PMC305729

Waters, J.B., M.B.A. Oldstone and K.M. Hahn. Changes in the cytoplasmic structure of cytotoxic T lymphocytes during target cell recognition and killing.  J.Immunology, 157: 3396-3403, 1996.

Lewicki, H., A. Tishon, P. Borrow, C.F. Evans, J.E. Gairin, K.M. Hahn, D.A. Jewell, I.A.Wilson, and M.B.A. Oldstone.  CTL escape viral variants.  I.  Generation and molecular characterization.  Virology, 210: 29-40, 1995.

Bark, I.C., K.M. Hahn, A.E. Ryabinin, and M.C. Wilson.  Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neuronal development.  Proc. Natl. Acad. Sci., USA 92: 1510-1514, 1995. PMC42549

Hahn, K.M., R. DeBiasio and D.L. Taylor.  Patterns of elevated free calcium and calmodulin activation in living cells.  Nature, 359: 736-738, 1992.             

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